26 Comments
User's avatar
Cassandra Is My Middle Name's avatar

As someone who exists in a hot tub daily, I’ve traded in my patch for gel. 2 pumps. One earlier in the day. And one later. I don’t think I absorb it as well as I did the patch. But it’s good enough for me.

Long live estrogen.

Holly Warner's avatar

They will pry my oral estradiol from my cold 🥶 ☠️ 🙌 haha. Great article!

Marths's avatar

Do you recommend oral estradiol once or twice daily ? How does it compare to Premarin oral ?

Dr. Amy B. Killen MD's avatar

Usually once daily. But it can be done either way.

Robert Watson's avatar

Excellent article! We are fighting hard to get estradiol patches/gels/pellets/injections approved as a Standard of Care for treating men with prostate cancer. Our efforts are very similar, in terms of providing a better Quality of Life for men with PCa and for women with osteoporosis/hot flashes. Check out our website at estradiolintiative.org. Bob

Theresa McGowan, MS, ATC, LPC's avatar

Great read, Amy. Seriously, thank you for reminding me of Elaine’s sponge-worthy episode. It’s an all-time classic! Keep bringing your knowledge, humor, and opinions. I’m here for all of it.

Elizabeth Stone's avatar

Thank you! I love your work and have really appreciated your substack so far.

I would love if you addressed estrogen injections (not the implants) at some point, I would prefer them (once a week, no pills or patch residue management) but not many seem willing to prescribe this way.

Jenny Fendig's avatar

@Mary Henry- You and @CathyT owe every single one of us an apology for being too racist to vote for a black woman and now we are stuck scrambling for our estrogen patches while the world burns because of the man you elected.

CathyT's avatar

There is no gas shortage and seriously, I'm following you for your expertise on Menopause! I really do not care to hear about your political thoughts or opinions. Can you not just stay on your topic and leave the political commentary to others?

Dr. Amy B. Killen MD's avatar

It turns out I have opinions on many things. Feel free to unfollow. This is my Substack.

Dominika's avatar

It is not just political thoughts or opinions. These are facts affecting our daily lives. Sorry turns out politics and voting matters!

Dr. Amy B. Killen MD's avatar

Turns out. Who would have thought? 😏

Lynn Marie Morski's avatar

I'm on .05, so I ordered the .1 (which is all walgreens had) and cut them in half to get my actual dose. What will be harder is when I have to use the .075s I got during the last shortage - cutting them in thirds and mixing and matching may be a disaster lol

Dominika's avatar

You would still use halves which is not the end of the world but I hear you. I've been cutting for a while now and it is sometimes comical.

Nadia's avatar

Wow. I’m on 4 pumps of estrogel; they said this was the equivalent to the 100mcg estrodot patch I was on… but if I am reading it right your chart says I’m basically on double the dose I was…?!

Dr. Amy B. Killen MD's avatar

The numbers in the tool are based on the pharmacokinetics data from the medication manufacturer. They are averages and certainly can't tell you what your actual response to that drug is. Some women are much better absorbers than others. So, take the information with a grain of salt.

Nadia's avatar

… certainly eye opening nonetheless… I’m in the UK and they don’t / won’t test levels as they believe it’s pointless here… I might be flying up to the moon high on estrogen on the dose I’m on! 😅 🚀

Nadia's avatar

… I felt way way better on estrodot though…

Jursy Gurl's avatar

I get an injectable pellet containing estradiol and was unaware of this patch shortage. Sounds like an opportunity for American Women’s Health Industry to manufacture a patch in our own country rather than complain about a shortage created by a trade war. Our health and medicines should not be compromised by having dependencies on unfriendly, undermining countries such as CCP.

Personally, I would prefer that my supplements, foods and anything I consume in my body or apply to my skin would be made in America and properly scrutinized or kept organic. To be mad at one man for waking up the country to our laziness or stupid climate excuses for not manufacturing our own products is kind of a cheap shot. IMO

Katy Hoeft's avatar

I finally looked at your conversion tool! WOW! Amazing! Thank you for putting all of that in 1 place!!!!! Fantastic! Katy

Mary's avatar

I’m curious your thoughts on estradiol oral troches? I don’t think the patch (for me) delivers consistent dosing. As well as a high sauna and bath user.

Elisa Nutku's avatar

thank you for your excellent article. please Amy could you talk about the oestrogen implant. the patch shortage here ( Australia ) is " normal" for us. I found out about implants , size of a grain of rice and last 4 to 6 months. Life changing stuff! I am onto my fourth one. Way better than patches and all the rest.

love your work, opinions and all !

Mary Henry's avatar

You know you really should stay out of the political name calling business. You just lost another follower. Learn to keep certain things to yourself.

Kristen Talley's avatar

Don’t let the door hit you on the way out, Mary!

Dr. Killen, thank you for the very helpful and practical information for riding out this shortage and for explaining why it’s happening. As a wine importer, my business has been hit quite directly by the tariffs. I wasn’t aware that they were directly impacting my healthcare in this way

Amy - The Tonic's avatar

Very helpful, thank you!