It feels a bit like I’m part of a small fetish group, one where we talk about our weird preferences behind closed doors because we’re sure that nobody else will share our enjoyment of wearing furry animal costumes or sucking on toes. But, instead of furries and feet fetishes, I have an oral estradiol fetish But, before you shun me and toss me out of your polite society of hormone specialists, let me explain.
I have tried all different bioidentical transdermal estradiol and oral estradiol. The oral estradiol removes my joint pain completely but the transdermal does not
Wow...12 months of hard work right there!! Thank you! 🤩 For me, the benefits, far outweigh any "possible" risk. At 53... cancer can get f*****. I always tolerated the oral contraceptive well, so would like to try the combined HRT.
Personally I found a difference between estradiol hemihydrate gel and estradiol. I hope not to have taken the route outside bioidentical hormones, but it is a world of difference in symptom management (in peri).
A question about your article. What if a women is 13 years post menopausal but has a calcium score of zero and no other risk factors, would you feel oral estrogen is the right hrt?
In highly reliable and compliant patients with known clotting disorders who are on anticoagulation therapy and who also have risk factors putting them at higher ASCVD risk, would you still only go with topical estradiol, not a pill? I struggle with this… interested in your perspective.
What is your view of the difference between oral and transdermal estradiol? What if it's just because one can achieve a higher level in the body with oral vs transdermal? I don't see that the research even considered this?
I'm sorry for the way I phrased this...obviously you gave your opinion about oral estradiol being better. My personal experience is that the highest dose transdermal sometimes doesn't raise my estradiol.... especially when training hard.
Does research fail to question the levels being the difference? This could even be the case with the epithelial experiment
I agree! That is what I see also with many patients! With low dose transdermal estradiol levels aren’t optimal! So I would argue that most studies were not done using optimal doses of TD estradiol and that’s why we don’t see as much prevention than with oral estradiol… @amy whatcha think?
Thank you for this info. I’ve been taking .5 estradiol for at least year now and have tried to increase my dose to 1 mg unsuccessfully due to breast soreness and overall weight gain. Do you think that “some” estradiol is better than none at all, or is there an optimal range for a 46-year-old to shoot for? I’d appreciate your thoughts. :)
I have tried all different bioidentical transdermal estradiol and oral estradiol. The oral estradiol removes my joint pain completely but the transdermal does not
Thanks for sharing!
I'm surprised so few people are talking about Estetrol, since it may not have as much of a risk for clotting. I suppose it's too new?
This is amazing! Thank you!
Thank you for this thorough article. Your explanation is excellent
Wow...12 months of hard work right there!! Thank you! 🤩 For me, the benefits, far outweigh any "possible" risk. At 53... cancer can get f*****. I always tolerated the oral contraceptive well, so would like to try the combined HRT.
Appreciate the feedback. Best of luck!
Amy, thanks for sharing your incredibly insightful research summary
Personally I found a difference between estradiol hemihydrate gel and estradiol. I hope not to have taken the route outside bioidentical hormones, but it is a world of difference in symptom management (in peri).
A question about your article. What if a women is 13 years post menopausal but has a calcium score of zero and no other risk factors, would you feel oral estrogen is the right hrt?
Excellent article! Thank you for going all that research!
Wow Amy amazing write up thank you so much much love for the education 💕💕👑👑
In highly reliable and compliant patients with known clotting disorders who are on anticoagulation therapy and who also have risk factors putting them at higher ASCVD risk, would you still only go with topical estradiol, not a pill? I struggle with this… interested in your perspective.
Is oral estradiol taken once or twice a day ? So much confusion about it.
What is your view of the difference between oral and transdermal estradiol? What if it's just because one can achieve a higher level in the body with oral vs transdermal? I don't see that the research even considered this?
I'm sorry for the way I phrased this...obviously you gave your opinion about oral estradiol being better. My personal experience is that the highest dose transdermal sometimes doesn't raise my estradiol.... especially when training hard.
Does research fail to question the levels being the difference? This could even be the case with the epithelial experiment
I agree! That is what I see also with many patients! With low dose transdermal estradiol levels aren’t optimal! So I would argue that most studies were not done using optimal doses of TD estradiol and that’s why we don’t see as much prevention than with oral estradiol… @amy whatcha think?
Thank you for this info. I’ve been taking .5 estradiol for at least year now and have tried to increase my dose to 1 mg unsuccessfully due to breast soreness and overall weight gain. Do you think that “some” estradiol is better than none at all, or is there an optimal range for a 46-year-old to shoot for? I’d appreciate your thoughts. :)
Yes, some is better than none.